ncRNA name | TLR2 siRNA |
ncRNA Category | siRNA |
Disease name | Fusarium solani keratitis |
Species | Homo sapiens |
Tissues/Cell_line | human corneal epithelial cells (HCECs) |
Methods | siRNA transfection, qRT-PCR, immunoblot, flow cytometry |
Expression pattern | associated |
Functional description | HCECs express Dectin-1 and TLR2. HCECs demonstrated upregulation of AMPs hBD2 and cathelicidin LL37 following exposure to heat-inactivated F. solani or PAMPs. TLR2 and Dectin-1 knockdown and BAY 61-3606 treatment decreased AMP mRNA upregulation confirming PRR involvement. |
PubMed ID | 28460048 |
Year | 2017 |
Title | Role of Pattern Recognition Receptors in the Modulation of Antimicrobial Peptide Expression in the Corneal Epithelial Innate Response to F. solani. |
Drug-related ncRNA | NO |
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